This article investigates French Academician-Michel Serres' educational epistemology. Nowadays, individual discipline as the only means of teaching knowledge has been in question in higher education in the world. Thus, liberal education is taken into consideration as one of the most important reform of curriculum. However, concerning about the liberal education, we cannot but analyze and interrogate the fundamental epistemology of disciplines, deconstruct their elements and reintegrate them. From Serres' point of view, he argues that we can not divide the knowledge into the natural science and the human science. His educational epistemology is a flame-knowledge where the natural science and the human science mix into. He also designs common programs for the first years of College. In fact, the main idea of liberal education is to form students as a self-organization man who is capable of constructing a meaningful, organized and connected world by himself; and to form students as a human who like to spontaneously transgress the boundary of discipline and knowledge. Therefore, his educational epistemology seeks the "North West Passage" between all knowledge and hopes to come into being a "troubadour of knowledge" who will never stop transgressing, mixing all knowledge, learning, and being toward others. The "troubadour of knowledge" represents the future picture of "a man of tomorrow."